The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering

Nearly all cellular and disease related functions of the transcriptional co-activator lens epithelium-derived growth factor (LEDGF/p75) involve tethering of interaction partners to chromatin via its conserved integrase binding domain (IBD), but little is known about the mechanism of in vivo chromati...

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Main Authors: Hendrix, Jelle, Gijsbers, Rik, De Rijck, Jan, Voet, Arnout, Hotta, Jun-ichi, McNeely, Melissa, Hofkens, Johan, Debyser, Zeger, Engelborghs, Yves
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Gene Regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045605/
https://ncbi.nlm.nih.gov/pubmed/20974633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq933
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