Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae

The target of rapamycin (TOR) kinase is an evolutionarily conserved key regulator of eukaryotic cell growth and proliferation. Recently, it has been reported that inhibition of TOR signaling pathway can delay aging and extend lifespan in several eukaryotic organisms, but how lifespan extension is me...

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Bibliographic Details
Main Authors: Ha, Cheol Woong, Huh, Won-Ki
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045593/
https://ncbi.nlm.nih.gov/pubmed/20947565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq895
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