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Stiffness detection and reduction in discrete stochastic simulation of biochemical systems
Typical multiscale biochemical models contain fast-scale and slow-scale reactions, where “fast” reactions fire much more frequently than “slow” ones. This feature often causes stiffness in discrete stochastic simulation methods such as Gillespie’s algorithm and the Tau-Leaping method leading to inef...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Institute of Physics
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3045418/ https://ncbi.nlm.nih.gov/pubmed/21303090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.3548838 |
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