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The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

BACKGROUND: Metabolic reprogramming resulting in enhanced glycolysis is a phenotypic trait of cancer cells, which is imposed by the tumor microenvironment and is linked to the down-regulation of the catalytic subunit of the mitochondrial H(+)-ATPase (β-F1-ATPase). The bioenergetic signature is a pro...

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Autors principals: Sánchez-Aragó, María, Cuezva, José M
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045315/
https://ncbi.nlm.nih.gov/pubmed/21303518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-19
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