The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies

The single nucleotide polymorphism 1858C>T in the PTPN22 gene is associated with type 1 diabetes (T1D) in several populations. Previous reports have suggested the association may be modified by HLA, as well as by islet autoantibodies. In a large case-control study of Swedish incident T1D patients...

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Hlavní autoři: Maziarz, Marlena, Janer, Marta, Roach, Jared, Hagopian, William, Palmer, Jerry P, Deutsch, Kerry, Sanjeevi, Carani B, Kockum, Ingrid, Breslow, Norman, Lernmark, Åke
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045194/
https://ncbi.nlm.nih.gov/pubmed/20445565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2010.12
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