Paradoxical anticonvulsant activity of the excitatory amino acid N-methyl-D-aspartate in the rat caudate-putamen.

We used limbic seizures induced in rats by systemic injection of the cholinergic agonist pilocarpine (380 mg/kg; i.p.) to study the neuronal pathways within the basal ganglia that modulate seizure threshold. N-Methyl-D-aspartate (N-Me-D-Asp) is an excitatory amino acid derivative that is a powerful...

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Autors principals: Turski, L, Meldrum, B S, Cavalheiro, E A, Calderazzo-Filho, L S, Bortolotto, Z A, Ikonomidou-Turski, C, Turski, W A
Format: Artigo
Idioma:Inglês
Publicat: 1987
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC304502/
https://ncbi.nlm.nih.gov/pubmed/3550795
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