Paradoxical anticonvulsant activity of the excitatory amino acid N-methyl-D-aspartate in the rat caudate-putamen.

We used limbic seizures induced in rats by systemic injection of the cholinergic agonist pilocarpine (380 mg/kg; i.p.) to study the neuronal pathways within the basal ganglia that modulate seizure threshold. N-Methyl-D-aspartate (N-Me-D-Asp) is an excitatory amino acid derivative that is a powerful...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Turski, L, Meldrum, B S, Cavalheiro, E A, Calderazzo-Filho, L S, Bortolotto, Z A, Ikonomidou-Turski, C, Turski, W A
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1987
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304502/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3550795/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.6.1689
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