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Hypoxia-inducible Factor α Subunit Stabilization by NEDD8 Conjugation Is Reactive Oxygen Species-dependent
Hypoxia-inducible factor α proteins (HIF-αs) are regulated oxygen dependently and transactivate numerous genes essential for cellular adaptation to hypoxia. NEDD8, a member of the ubiquitin-like family, covalently binds to its substrate proteins, and thus, regulates their stabilities and functions....
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044952/ https://ncbi.nlm.nih.gov/pubmed/21193393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.188706 |
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