Hypoxia-inducible Factor α Subunit Stabilization by NEDD8 Conjugation Is Reactive Oxygen Species-dependent

Hypoxia-inducible factor α proteins (HIF-αs) are regulated oxygen dependently and transactivate numerous genes essential for cellular adaptation to hypoxia. NEDD8, a member of the ubiquitin-like family, covalently binds to its substrate proteins, and thus, regulates their stabilities and functions....

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Bibliografiska uppgifter
Huvudupphovsmän: Ryu, Ji-Hye, Li, Shan-Hua, Park, Hyoung-Sook, Park, Jong-Wan, Lee, ByungLan, Chun, Yang-Sook
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044952/
https://ncbi.nlm.nih.gov/pubmed/21193393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.188706
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