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Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.

Recombinant human interleukin 2 purified from Escherichia coli has limited solubility at neutral pH and a short circulatory half-life. This recombinant interleukin 2 was chemically modified by an active ester of polyethylene glycol. The modified interleukin 2 was purified by hydrophobic interaction...

詳細記述

保存先:
書誌詳細
主要な著者: Katre, N V, Knauf, M J, Laird, W J
フォーマット: Artigo
言語:Inglês
出版事項: 1987
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC304459/
https://ncbi.nlm.nih.gov/pubmed/3494243
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