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Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number
The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼−0.5 over a range of 3–30...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044411/ https://ncbi.nlm.nih.gov/pubmed/21292990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019706108 |
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