Poly(ADP-ribose) may signal changing metabolic conditions to the chromatin of mammalian cells.
In mammalian cells, NAD+ serves a dual role as a respiratory coenzyme and as a substrate for the posttranslational poly(ADP-ribose) modification of chromatin proteins, catalyzed by the nuclear enzyme poly(ADP-ribose) polymerase [NAD+ ADP-ribosyltransferase, EC 2.4.2.30]. Biological evidence strongly...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1987
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304412/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3103132/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.5.1286 |
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