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Tem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function
The mitotic exit network (MEN) is a signaling cascade that triggers inactivation of the mitotic cyclin-dependent kinases and exit from mitosis. The GTPase Tem1 localizes on the spindle pole bodies (SPBs) and initiates MEN signaling. Tem1 activity is inhibited until anaphase by Bfa1-Bub2. These prote...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044116/ https://ncbi.nlm.nih.gov/pubmed/21321099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201007044 |
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