Distinct DNA methylation changes highly correlated with chronological age in the human brain

Methylation at CpG sites is a critical epigenetic modification in mammals. Altered DNA methylation has been suggested to be a central mechanism in development, some disease processes and cellular senescence. Quantifying the extent and identity of epigenetic changes in the aging process is therefore...

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Main Authors: Hernandez, Dena G., Nalls, Michael A., Gibbs, J. Raphael, Arepalli, Sampath, van der Brug, Marcel, Chong, Sean, Moore, Matthew, Longo, Dan L., Cookson, Mark R., Traynor, Bryan J., Singleton, Andrew B.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043665/
https://ncbi.nlm.nih.gov/pubmed/21216877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq561
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