Na+ channels as sites of action of the cardioactive agent DPI 201-106 with agonist and antagonist enantiomers.

This paper shows the interaction of the cardiotonic agent 4-[3-(4-diphenylmethyl-1-piperazinyl)-2-hydroxypropoxy]-1H-indole- 2-carbonitrile (DPI 201-106) and its optic enantiomers R-DPI (205-429) and S-DPI (205-430) with the Na+ channel of a variety of excitable cells. Voltage-clamp experiments show...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Romey, G, Quast, U, Pauron, D, Frelin, C, Renaud, J F, Lazdunski, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2433694/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.3.896
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