Induced Conformational Changes in the Activation of the Pseudomonas aeruginosa type III Toxin, ExoU

ExoU is a 74-kDa, water-soluble toxin injected directly into mammalian cells through the type III secretion system of the opportunistic pathogen, Pseudomonas aeruginosa. Previous studies have shown that ExoU is a Ca(2+)-independent phospholipase that requires a eukaryotic protein cofactor. One prote...

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Main Authors: Benson, Marc A., Komas, Steven M., Schmalzer, Katherine M., Casey, Monika S., Frank, Dara W., Feix, Jimmy B.
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2011
主題:
Protein
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043214/
https://ncbi.nlm.nih.gov/pubmed/21354407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.01.056
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