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Hypoxia Triggers Major Metabolic Changes in AML Cells without Altering Indomethacin-Induced TCA Cycle Deregulation

[Image: see text] Our previous studies have shown that the nonsteroidal anti-inflammatory drug indomethacin exhibits antileukemic activity in vitro and can inhibit the aldo-keto reductase AKR1C3, which we identified as a novel target in acute myeloid leukemia. However, the antileukemic actions of in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lodi, Alessia, Tiziani, Stefano, Khanim, Farhat L., Drayson, Mark T., Günther, Ulrich L., Bunce, Christopher M., Viant, Mark R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2010
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042854/
https://ncbi.nlm.nih.gov/pubmed/20886892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb900300j
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