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IL-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells
Infection with HIV-1 induces a progressive deterioration of the immune system that ultimately leads to AIDS. Mouse models indicate that the common gamma chain (γ(c))- sharing cytokine interleukin (IL)-21 and its receptor (IL-21R) play a crucial role in maintaining polyfunctional T cell responses dur...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3042849/ https://ncbi.nlm.nih.gov/pubmed/20977918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2010.10.015 |
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