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Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

Fyn, an Src kinase family member, acts as a negative regulator of NF-E2-related factor 2 (Nrf2). Under stressful conditions, Nrf2 translocates into the nucleus and binds to the antioxidant response element (ARE), activating defensive gene expression. Once Nrf2 completes activation, Fyn phosphorylate...

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Bibliografiske detaljer
Main Authors: Kaspar, James W., Jaiswal, Anil K.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042843/
https://ncbi.nlm.nih.gov/pubmed/21097520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-171553
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