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A rearranged EP300 gene in the human B-cell lymphoma cell line RC-K8 encodes a disabled transcriptional co-activator that contributes to cell growth and oncogenicity
Human diffuse large B-cell lymphoma cell line RC-K8 has an altered EP300 locus that encodes a C-terminally truncated histone acetyltransferase (HAT) protein (p300ΔC). We now show that p300ΔC contains 1047 N-terminal amino acids of p300 fused to 25 amino acids encoded by sequences from chromosome 6....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3042717/ https://ncbi.nlm.nih.gov/pubmed/21232847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2010.12.018 |
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