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Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats

RATIONALE: Tobacco withdrawal is characterized by a negative mood state and relatively mild somatic symptoms. Increased noradrenergic transmission has been reported to play an important role in opioid withdrawal, but little is known about the role of noradrenergic transmission in nicotine withdrawal...

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Main Authors: Bruijnzeel, Adrie W., Bishnoi, Mahendra, van Tuijl, Irma A., Keijzers, Kim F. M., Yavarovich, Kate R., Pasek, Tim M., Ford, Jenna, Alexander, Jon C., Yamada, Hidetaka
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042243/
https://ncbi.nlm.nih.gov/pubmed/20697697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-010-1970-0
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