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Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach

BACKGROUND: Interferon-gamma (IFNγ) is a multifunctional cytokine with antifibrotic and antiproliferative efficiency. We previously found that pancreatic stellate cells (PSC), the main effector cells in cancer-associated fibrosis, are targets of IFNγ action in the pancreas. Applying a combined exper...

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Detalhes bibliográficos
Main Authors: Lange, Falko, Rateitschak, Katja, Fitzner, Brit, Pöhland, Ralf, Wolkenhauer, Olaf, Jaster, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042009/
https://ncbi.nlm.nih.gov/pubmed/21310022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-13
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