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Distinct antifibrogenic effects of erlotinib, sunitinib and sorafenib on rat pancreatic stellate cells

AIM: To study if three clinically available small molecule kinase inhibitors (SMI), erlotinib, sunitinib and sorafenib, exert antifibrogenic effects on pancreatic stellate cells (PSC) and analyze the basis of their action. METHODS: Cultured rat PSC were exposed to SMI. Cell proliferation and viabili...

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Detalhes bibliográficos
Main Authors: Elsner, Anne, Lange, Falko, Fitzner, Brit, Heuschkel, Martin, Krause, Bernd Joachim, Jaster, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069318/
https://ncbi.nlm.nih.gov/pubmed/24976727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v20.i24.7914
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