O(6)-Methylguanine-DNA Methyltransferase (MGMT) mRNA Expression Predicts Outcome in Malignant Glioma Independent of MGMT Promoter Methylation

BACKGROUND: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with concomitant and adjuvant temozolomide or temozolomide al...

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Détails bibliographiques
Auteurs principaux: Kreth, Simone, Thon, Niklas, Eigenbrod, Sabina, Lutz, Juergen, Ledderose, Carola, Egensperger, Rupert, Tonn, Joerg C., Kretzschmar, Hans A., Hinske, Ludwig C., Kreth, Friedrich W.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041820/
https://ncbi.nlm.nih.gov/pubmed/21365007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017156
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