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Survival Benefit With Proapoptotic Molecular and Pathologic Responses From Dual Targeting of Mammalian Target of Rapamycin and Epidermal Growth Factor Receptor in a Preclinical Model of Pancreatic Neuroendocrine Carcinogenesis

PURPOSE: Pancreatic neuroendocrine tumors (PNETs), although rare, often metastasize, such that surgery, the only potentially curative therapy, is not possible. There is no effective systemic therapy for patients with advanced PNETs. Therefore, new strategies are needed. Toward that end, we investiga...

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Autori principali: Chiu, Christopher W., Nozawa, Hiroaki, Hanahan, Douglas
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041788/
https://ncbi.nlm.nih.gov/pubmed/20823411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.28.0198
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