Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast

Spinocerebellar ataxia 10 (SCA10) is an autosomal dominant disease caused by large-scale expansions of the (ATTCT)(n) repeat within an intron of the human ATXN10 gene. In contrast to other expandable repeats, this pentanucleotide repeat does not form stable intra- or interstranded DNA structures, be...

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Detalhes bibliográficos
Main Authors: Cherng, Nicole, Shishkin, Alexander A., Schlager, Lucas I., Tuck, Ryan H., Sloan, Laura, Matera, Robert, Sarkar, Partha S., Ashizawa, Tetsuo, Freudenreich, Catherine H., Mirkin, Sergei M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041125/
https://ncbi.nlm.nih.gov/pubmed/21282659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009409108
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