Grb-2–associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A–endothelial NOS pathway

The intracellular signaling mechanisms underlying postnatal angiogenesis are incompletely understood. Herein we show that Grb-2–associated binder 1 (Gab1) plays a critical role in ischemic and VEGF-induced angiogenesis. Endothelium-specific Gab1 KO (EGKO) mice displayed impaired angiogenesis in the...

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Bibliographic Details
Main Authors: Lu, Yao, Xiong, Yan, Huo, Yingqing, Han, Jingyan, Yang, Xiao, Zhang, Rongli, Zhu, De-Sheng, Klein-Heßling, Stefan, Li, Jun, Zhang, Xiaoyu, Han, Xiaofan, Li, Yanli, Shen, Bin, He, Yulong, Shibuya, Masabumi, Feng, Gen-Sheng, Luo, Jincai
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041066/
https://ncbi.nlm.nih.gov/pubmed/21282639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009395108
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