Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Sensory and signaling pathways are exquisitely organized in primary cilia. Bardet-Biedl syndrome (BBS) patients have compromised cilia and signaling. BBS proteins form the BBSome, which binds Rabin8, a guanine nucleotide exchange factor (GEF) activating the Rab8 GTPase, required for ciliary assembly...

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Bibliografiske detaljer
Main Authors: Westlake, Christopher J., Baye, Lisa M., Nachury, Maxence V., Wright, Kevin J., Ervin, Karen E., Phu, Lilian, Chalouni, Cecile, Beck, John S., Kirkpatrick, Donald S., Slusarski, Diane C., Sheffield, Val C., Scheller, Richard H., Jackson, Peter K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041065/
https://ncbi.nlm.nih.gov/pubmed/21273506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018823108
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