Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Sensory and signaling pathways are exquisitely organized in primary cilia. Bardet-Biedl syndrome (BBS) patients have compromised cilia and signaling. BBS proteins form the BBSome, which binds Rabin8, a guanine nucleotide exchange factor (GEF) activating the Rab8 GTPase, required for ciliary assembly...

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Main Authors: Westlake, Christopher J., Baye, Lisa M., Nachury, Maxence V., Wright, Kevin J., Ervin, Karen E., Phu, Lilian, Chalouni, Cecile, Beck, John S., Kirkpatrick, Donald S., Slusarski, Diane C., Sheffield, Val C., Scheller, Richard H., Jackson, Peter K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041065/
https://ncbi.nlm.nih.gov/pubmed/21273506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018823108
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