Targeted tumor gene therapy based on loss of IGF2 imprinting

Loss of imprinting (LOI) of the insulin-like growth factor 2 gene (IGF2) is one of the most common epigenetic abnormalities seen in human neoplasms. LOI may be associated with the lack of Zinc-finger DNA binding protein CTCF-mediated enhancer insulation, presumably due to the gain of methylation on...

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Autores principales: Pan, Yuqin, He, Bangshun, Li, Tao, Zhu, Chan, Zhang, Lirong, Wang, Bo, Xu, Yongfei, Qu, Lili, Hoffman, Andrew R, Wang, Shukui, Hu, Jifan
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2010
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040838/
https://ncbi.nlm.nih.gov/pubmed/20592487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.3.12442
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