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Differential TRAF3 utilization by a variant human CD40 receptor with enhanced signaling
CD40 is required for T-dependent humoral immunity, but can also contribute to the pathogenesis of autoimmunity and B cell malignancy. The TNF receptor associated factor (TRAF)2 and TRAF6 adaptor proteins are positive regulators of CD40 signaling required to activate downstream kinase cascades and tr...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3040440/ https://ncbi.nlm.nih.gov/pubmed/21041727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000135 |
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