FLT3 mutations in canine acute lymphocytic leukemia

BACKGROUND: FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. Mutations leading to constitutively active FLT3, including internal tandem duplications of the juxtamembrane domain (ITD), result in continuous cellular proliferation, resistance to apo...

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Main Authors: Suter, Steven E, Small, George W, Seiser, Eric L, Thomas, Rachael, Breen, Matthew, Richards, Kristy L
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040160/
https://ncbi.nlm.nih.gov/pubmed/21272320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-38
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