mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells

Activating mutations of the FLT3 gene mediate leukemogenesis, at least in part, through activation of PI3K/AKT. The mammalian target of rapamycin (mTOR)-Raptor signaling pathway is known to act downstream of AKT. Here we show that the mTOR effectors, 4EBP1, p70S6K and rpS6, are highly activated in c...

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Autors principals: Chen, Weina, Drakos, Elias, Grammatikakis, Ioannis, Schlette, Ellen J, Li, Jiang, Leventaki, Vasiliki, Staikou-Drakopoulou, Efi, Patsouris, Efstratios, Panayiotidis, Panayiotis, Medeiros, L Jeffrey, Rassidakis, George Z
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993677/
https://ncbi.nlm.nih.gov/pubmed/21067588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-292
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