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Reduction of exacerbations by the PDE4 inhibitor roflumilast - the importance of defining different subsets of patients with COPD

BACKGROUND: As chronic obstructive pulmonary disease (COPD) is a heterogeneous disease it is unlikely that all patients will benefit equally from a given therapy. Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, has been shown to improve lung function in moderate and severe COPD but i...

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Detalhes bibliográficos
Main Authors: Rennard, Stephen I, Calverley, Peter MA, Goehring, Udo M, Bredenbröker, Dirk, Martinez, Fernando J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040135/
https://ncbi.nlm.nih.gov/pubmed/21272339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-12-18
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