A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells.

We investigated the enzymatic mechanisms responsible for AA oxygenation in homogenous cell suspensions obtained by trypsinization of epidermis from healthy subjects. Cell incubation with AA (0.3-150 microM) invariably resulted in the predominant generation of a compound identified as 12-hydroxyeicos...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Holtzman, M J, Turk, J, Pentland, A
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 1989
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2509517/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114319
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