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KT5823 Differentially Modulates Sodium Iodide Symporter Expression, Activity, and Glycosylation between Thyroid and Breast Cancer Cells

Na(+)/I(−) symporter (NIS)-mediated iodide uptake into thyroid follicular cells serves as the basis of radioiodine therapy for thyroid cancer. NIS protein is also expressed in the majority of breast tumors, raising potential for radionuclide therapy of breast cancer. KT5823, a staurosporine-related...

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Detalhes bibliográficos
Main Authors: Beyer, Sasha, Lakshmanan, Aparna, Liu, Yu-Yu, Zhang, Xiaoli, Wapnir, Irene, Smolenski, Albert, Jhiang, Sissy
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040054/
https://ncbi.nlm.nih.gov/pubmed/21209020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0782
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