Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression

BACKGROUND: TACE/ADAM17 is a transmembranous protease that cleaves membrane-bound growth factors like EGFR ligands. TACE-dependent proteolysis is regulated by its inhibitor, tissue inhibitor of metalloproteinases 3 (TIMP3). This study analyses the role of TACE and TIMP3 mRNA expression in squamous c...

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Dettagli Bibliografici
Autori principali: Kornfeld, J-W, Meder, S, Wohlberg, M, Friedrich, R E, Rau, T, Riethdorf, L, Löning, T, Pantel, K, Riethdorf, S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
Soggetti:
Molecular Diagnostics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039790/
https://ncbi.nlm.nih.gov/pubmed/21102583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6606017
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