Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein–Taybi syndrome detected by aCGH

We demonstrate the utility of an exon coverage microarray platform in detecting intragenic deletions: one in exons 24–27 of the EP300 gene and another in exons 27 and 28 of the CREBBP gene in two patients with Rubinstein–Taybi syndrome (RSTS). RSTS is a heterogeneous disorder in which ∼45–55% of cas...

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Main Authors: Tsai, Anne Chun-Hui, J Dossett, Cherilyn, Walton, Carol S, E Cramer, Andrea, Eng, Patti A, Nowakowska, Beata A, Pursley, Amber N, Stankiewicz, Pawel, Wiszniewska, Joanna, Cheung, Sau Wai
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039495/
https://ncbi.nlm.nih.gov/pubmed/20717166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2010.121
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