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Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization
The p53 tumor suppressor plays a central role in integrating cellular responses to various stresses. Tight regulation of p53 is thus essential for the maintenance of genome integrity and normal cell proliferation. Previously, we reported that JFK, the only Kelch domain-containing F-box protein in hu...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039393/ https://ncbi.nlm.nih.gov/pubmed/21127074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.195115 |
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