Engineering Kunitz Domain 1 (KD1) of Human Tissue Factor Pathway Inhibitor-2 to Selectively Inhibit Fibrinolysis: PROPERTIES OF KD1-L17R VARIANT

Tissue factor pathway inhibitor-2 (TFPI-2) inhibits factor XIa, plasma kallikrein, and factor VIIa/tissue factor; accordingly, it has been proposed for use as an anticoagulant. Full-length TFPI-2 or its isolated first Kunitz domain (KD1) also inhibits plasmin; therefore, it has been proposed for use...

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Detalhes bibliográficos
Main Authors: Bajaj, Madhu S., Ogueli, Godwin I., Kumar, Yogesh, Vadivel, Kanagasabai, Lawson, Gregory, Shanker, Sreejesh, Schmidt, Amy E., Bajaj, S. Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039392/
https://ncbi.nlm.nih.gov/pubmed/21115497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191163
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