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Novel Folding and Stability Defects Cause a Deficiency of Human Glutathione Transferase Omega 1
The polymorphic deletion of Glu-155 from human glutathione transferase omega1 (GSTO1-1) occurs in most populations. Although the recombinant ΔGlu-155 enzyme expressed in Escherichia coli is active, the deletion causes a deficiency of the active enzyme in vivo. The crystal structure and the folding/u...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039386/ https://ncbi.nlm.nih.gov/pubmed/21106529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197822 |
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