Stable IgG-like Bispecific Antibodies Directed toward the Type I Insulin-like Growth Factor Receptor Demonstrate Enhanced Ligand Blockade and Anti-tumor Activity

Bispecific antibodies (BsAbs) target multiple epitopes on the same molecular target or different targets. Although interest in BsAbs has persisted for decades, production of stable and active BsAbs has hindered their clinical evaluation. Here, we describe the production and characterization of tetra...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Dong, Jianying, Sereno, Arlene, Snyder, William B., Miller, Brian R., Tamraz, Susan, Doern, Adam, Favis, Michael, Wu, Xiufeng, Tran, Hon, Langley, Emma, Joseph, Ingrid, Boccia, Antonio, Kelly, Rebecca, Wortham, Kathleen, Wang, Qin, Berquist, Lisa, Huang, Flora, Gao, Sharon X., Zhang, Ying, Lugovskoy, Alexey, Martin, Shelly, Gouvis, Heather, Berkowitz, Steven, Chiang, Gisela, Reff, Mitchell, Glaser, Scott M., Hariharan, Kandasamy, Demarest, Stephen J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039382/
https://ncbi.nlm.nih.gov/pubmed/21123183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.184317
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller