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Thiol-disulfide Redox Dependence of Heme Binding and Heme Ligand Switching in Nuclear Hormone Receptor Rev-erbβ

Rev-erbβ is a heme-binding nuclear hormone receptor that represses a broad spectrum of target genes involved in regulating metabolism, the circadian cycle, and proinflammatory responses. Here, we demonstrate that a thiol-disulfide redox switch controls the interaction between heme and the ligand-bin...

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Bibliografiset tiedot
Päätekijät: Gupta, Nirupama, Ragsdale, Stephen W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2011
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039370/
https://ncbi.nlm.nih.gov/pubmed/21123168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193466
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