Early and Late Events Induced by PolyQ-expanded Proteins: IDENTIFICATION OF A COMMON PATHOGENIC PROPERTY OF POLYQ-EXPANDED PROTEINS

To find a common pathogenetic trait induced by polyQ-expanded proteins, we have used a conditional expression system in PC12 cells to tune the expression of these proteins and analyze the early and late consequences of their expression. We find that expression for 3 h of a polyQ-expanded protein sti...

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Detalhes bibliográficos
Main Authors: Bertoni, Alessandra, Giuliano, Paola, Galgani, Mario, Rotoli, Deborah, Ulianich, Luca, Adornetto, Annagrazia, Santillo, Maria Rosaria, Porcellini, Antonio, Avvedimento, Vittorio Enrico
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039353/
https://ncbi.nlm.nih.gov/pubmed/21115499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156521
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