טוען...
Repeat Expansion Affects Both Transcription Initiation and Elongation in Friedreich Ataxia Cells
Expansion of a GAA·TTC repeat in the first intron of the frataxin (FXN) gene causes an mRNA deficit that results in Friedreich ataxia (FRDA). The region flanking the repeat on FRDA alleles is associated with more extensive DNA methylation than is seen on normal alleles and histone modifications typi...
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| Main Authors: | , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Biochemistry and Molecular Biology
2011
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039332/ https://ncbi.nlm.nih.gov/pubmed/21127046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194035 |
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