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The extracellular domain of fibroblast growth factor receptor 3 inhibits ligand-independent dimerization
Dysregulation of ligand-independent receptor tyrosine kinase (RTK) dimerization, which is the first step in RTK activation, leads to pathologies. A mechanistic understanding of the dimerization process is lacking, and this lack of basic knowledge is one bottleneck in developing effective RTK-targete...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039292/ https://ncbi.nlm.nih.gov/pubmed/21119106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001195 |
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