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Active site mapping and substrate specificity of bacterial Hen1, a manganese-dependent 3′ terminal RNA ribose 2′O-methyltransferase

The RNA methyltransferase Hen1 and the RNA end-healing/sealing enzyme Pnkp comprise an RNA repair system encoded by an operon-like cassette present in bacteria from eight different phyla. Clostridium thermocellum Hen1 (CthHen1) is a manganese-dependent RNA ribose 2′O-methyltransferase that marks the...

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Bibliographic Details
Main Authors: Jain, Ruchi, Shuman, Stewart
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039143/
https://ncbi.nlm.nih.gov/pubmed/21205839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2500711
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