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Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis
Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binucleine 2 is a highly isoform-specific inhibitor of Drosophila Aurora B kinase and we identify a single residue within the kinase active site that confers specificity for Aurora B. Using Bi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039078/ https://ncbi.nlm.nih.gov/pubmed/20804174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb1001685 |
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