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Deficits in Positive Reinforcement Learning and Uncertainty-Driven Exploration are Associated with Distinct Aspects of Negative Symptoms in Schizophrenia

BACKGROUND: Negative symptoms are core features of schizophrenia; however, the cognitive and neural basis for individual negative symptom domains remains unclear. Converging evidence suggests a role for striatal and prefrontal dopamine in reward learning and the exploration of actions that might pro...

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Detalhes bibliográficos
Main Authors: Strauss, Gregory P., Frank, Michael J., Waltz, James A., Kasanova, Zuzana, Herbener, Ellen S., Gold, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039035/
https://ncbi.nlm.nih.gov/pubmed/21168124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2010.10.015
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