Crystal structure of a γδ T-cell receptor specific for the human MHC class I homolog MICA

γδ T cells play important roles in bridging innate and adaptive immunity, but their recognition mechanisms remain poorly understood. Human γδ T cells of the V(δ)1 subset predominate in intestinal epithelia and respond to MICA and MICB (MHC class I chain-related, A and B; MIC) self-antigens, mediatin...

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Bibliographische Detailangaben
Hauptverfasser: Xu, Bin, Pizarro, Juan C., Holmes, Margaret A., McBeth, Christine, Groh, Veronika, Spies, Thomas, Strong, Roland K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038733/
https://ncbi.nlm.nih.gov/pubmed/21262824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015433108
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